Diets

Diets_Canine_HF.png

HF

Hydrolyzed for Food Intolerance

A natural option for dogs with food sensitivities, this veterinary-exclusive formula is made with readily digestible hydrolyzed salmon to help minimize the chance of adverse reactions to common proteins.

Features

Hydrolyzed salmon as the first ingredient and only animal protein

Mean molecular weight of 2kDa

97.3% of proteins less than 10kDa2

Appropriate protein levels to support skin healing and hair regrowth

ELISA and PCR performed on base ingredients and final diet to assure no cross-contamination

Mixed fiber sources to support a variety of gastrointestinal conditions

Elevated levels of EPA and DHA

Clinically shown to improve veterinarian rated skin lesion scores as well as the leading hydrolyzed poultry dry diet with fewer adverse events3

ST-O-ne GUARD formulated to manage urolithiasis1

Recommended for

Dermatologic

Chronic Otitis Externa

Cutaneous Adverse Food Reactions (CAFR)

Chronic Non-Seasonal Pruritic Dermatitis

Atopic Dermatitis

Pruritic Dermatitis

Gastrointestinal

Diet-Responsive Chronic Enteropathy

Intestinal Dysbiosis

Colitis

Inflammatory Bowel Disease

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NP

Novel Protein Alligator

Starting with real alligator — a single protein source rarely associated with food intolerance in dogs — this veterinary-exclusive formula is designed to nutritionally manage inflammatory skin and GI diseases in dogs who experience adverse food reactions.

Features

Featuring alligator as the first ingredient and only animal protein, for a truly novel protein source

ELISA and PCR performed on base ingredients and final diet to assure no cross-contamination

Elevated omega-3 fatty acids from alligator, fish oil, and flax seeds

Mixed fiber sources to support GI conditions

Complete and balanced for all life stages (dry formula)

ST-O-ne GUARD formulated to manage urolithiasis1

Recommended for

Dermatologic

Chronic Otitis Externa

Cutaneous Adverse Food Reactions (CAFR)

Chronic Non-Seasonal Pruritic Dermatitis

Atopic Dermatitis

Pruritic Dermatitis

Gastrointestinal

Diet-Responsive Chronic Enteropathy

Intestinal Dysbiosis

Colitis

Inflammatory Bowel Disease

Diets_Canine_GI.png

GI

Gastrointestinal Support

For dogs with gastrointestinal troubles, this veterinary-exclusive formula is made with easily digestible ingredients and prebiotic fibers to help balance and maintain a healthy gut.

Features

Prebiotic fibers like FOS (fructooligosaccharides) and chicory root to support a healthy microbiome for gastrointestinal health

Rich in EPA and DHA reduce intestinal inflammatory response

Clinically proven to improve stool quality and result in quicker resolution of actute diarrhea4

Highly digestible5

Complete and balanced for growth and maintenance*
*excludes large breed puppies

ST-O-ne GUARD formulated to manage urolithiasis1

Recommended for

Acute or Chronic Gastroenteritis

Gastritis/Ulcers

Small & Large Bowel Diarrhea

Motility/Emptying Disorders

Exocrine Pancreatic Insufficiency

Pancreatitis (nonhyperlipidemic in dogs)

Chronic Enteropathies

Antibiotic-Responsive Diarrhea

Colitis

Constipation

Intestinal Dysbiosis

Diets_Canine_GILowFat.png

GI

Gastrointestinal Support Low Fat

For dogs who have trouble digesting fat, this veterinary-exclusive formula is a reduced-fat version of our GI Support formula, with easily digestible ingredients and prebiotic fibers to help balance and maintain a healthy gut.

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Features

High digestibility for optimal nutrient absorption

Prebiotic fibers like FOS (fructooligosaccharides) and chicory root to support a healthy microbiome for gastrointestinal health

Rich in EPA and DHA reduce intestinal inflammatory response

Complete and balanced for long term feeding adult dogs

ST-O-ne GUARD formulated to manage urolithiasis1

Recommended for

Pancreatitis

Hyperlipidemia

Lymphangiectasia

Protein-losing enteropathy

Exocrine pancreatic insufficiency

Acute gastrointestinal illness

Chronic enteropathies

Other gastrointestinal diseases requiring a low-fat diet

Not recommended for

Growth, pregnancy, or lactation

Diets_Canine_KS.png

KS

Kidney Support

This veterinary-exclusive formula is designed with controlled levels of protein to support healthy kidney function in dogs. It also contains restricted mineral levels and vital nutrients to support overall health.

Features

Controlled protein levels, controlled phosphorus, controlled sodium

Rich in EPA and DHA

With added L-carnitine, Vitamin E, and Carotenoids

Highly digestible protein sources (chicken, egg)

Suitable for all IRIS stages

Highly palatable

Nutrition to benefit animals with cardiac disease6

High digestibility

ST-O-ne GUARD formulated for calcium oxalate prevention

Indications

Kidney disease

Calcium oxalate urolithiasis

Cardiac disease

Not recommended for

Struvite urolithiasis

Growth, pregnancy or lactation

Diets_Canine_WU.png

W+U

Weight Management + Urinary Care

For dogs who need help with weight management and urinary care, this veterinary-exclusive formula is made with the ideal levels of fat and calories to help dogs with weight loss, plus controlled mineral levels to support urinary health.

Features

Clinically proven nutrition to generate a urine a pH of 6.0-6.48

Controlled magnesium, sodium, and other mineral levels to limit urolith formation9

High in mixed fiber sources such as flaxseed and chicory root to promote satiety and prevent weight loss

Moderately high protein levels to help improve glycemic control10

Clinically proven nutrition to lower serum insulin and leptin levels with weight loss11

Clinically proven nutrition to reduce body fat by 37.5% and body weight by 16.3% in just two months11

L-carnitine to decrease body fat and maintain lean muscle12

Betaine to support fat oxidation12

ST-O-ne GUARD formulated to dissolve and prevent struvite urolithiasis and prevent calcium oxalate urolithiasis7

Indications

Weight Management

Weight management for obese or overweight dogs

Helps to maintain lean muscle mass

Dogs prone to lower urinary tract disease

Urinary Care

Helps to limit the formation of struvite uroliths

Dissolution of pure struvite uroliths

Helps to limit the formation of calcium oxalate urolithiasis

Not recommended for

Growth, pregnant, or lactating life stages

Use of concurrent urinary acidifier

Diets_Canine_WM.png

W+M

Weight Management + Mobility Support

This veterinary-exclusive formula contains optimally balanced caloric and nutrient levels to maintain healthy body weight and lean muscle, plus EPA, glucosamine, and chondroitin to support joint health and mobility.

Features

Clinically proven nutrition to improve arthritic scores by 20% over 2 months13

Increased dietary fiber from tomato pomace, chicory root, and powdered cellulose to promote satiety

Moderately high protein levels to help improve glycemic control10

Clinically proven nutrition to lower serum insulin and leptin levels 11

Clinically proven nutrition to reduce body fat by 37.5% and reduce body weight by 16.3% in just two months11

L-carnitine to decrease body fat and maintain lean muscle12

Betaine to support fat oxidation14

Naturally derived glucosamine from shrimp meal with added chondroitin sulfate

ST-O-ne GUARD formulated to manage urolithiasis1

Recommended for

Weight management for obese or overweight dogs

Helps to maintain lean muscle mass

Degenerative Joint Disease

Helps to limit the formation of struvite uroliths

Dissolution of pure struvite uroliths

Not recommended for

Growth

Diets_Feline_HF.png

HF

Hydrolyzed for Food Intolerance

A natural option for cats with food sensitivities, this veterinary-exclusive formula is made with readily digestible hydrolyzed salmon to help minimize the chance of adverse reactions to common proteins.

Features

Hydrolyzed salmon as the first ingredient and only animal protein

Mean molecular weight of 2kDa

97.3% of proteins less than 10kDa2

Elevated protein levels to support skin healing and hair regrowth

ELISA performed on base ingredients and final diet to assure no cross-contamination

Mixed fiber sources to support a variety of gastrointestinal conditions

Elevated levels of EPA and DHA

ST-O-ne GUARD formulated to manage urolithiasis1

Recommended for

Dermatologic

Chronic Otitis Externa

Cutaneous Adverse Food Reactions (CAFR)

Eosinophilic Granulomatous Disease

Chronic Non-Seasonal Pruritic Dermatitis

Atopic Dermatitis

Pruritic Dermatitis

Gastrointestinal

Diet-Responsive Chronic Enteropathy

Intestinal Dysbiosis

Colitis

Inflammatory Bowel Disease

Diets_Feline_NP.png

NP

Novel Protein Alligator

Starting with real alligator — a single protein source rarely associated with food intolerance in cats — this veterinary-exclusive formula is designed to nutritionally manage inflammatory skin and GI diseases in cats who experience adverse food reactions.

Features

Featuring alligator as the first ingredient and only animal protein, for a truly novel protein source

ELISA and PCR performed on base ingredients and final diet to assure no cross-contamination

Elevated omega-3 fatty acids from alligator, fish oil, and flax seeds

Mixed fiber sources to support GI conditions

Complete and balanced for all life stages (dry formula)

ST-O-ne GUARD formulated to manage urolithiasis1

Recommended for

Dermatologic

Chronic Otitis Externa

Cutaneous Adverse Food Reactions (CAFR)

Eosinophilic Granulomatous Disease

Chronic Non-Seasonal Pruritic Dermatitis

Atopic Dermatitis

Pruritic Dermatitis

Diet-Responsive Chronic Enteropathy

Intestinal Dysbiosis

Gastrointestinal

Colitis

Inflammatory Bowel Disease

Diets_Feline_GI.png

GI

Gastrointestinal Support

For cats with gastrointestinal troubles, this veterinary-exclusive formula is made with easily digestible ingredients and prebiotic fibers to help balance and maintain a healthy gut.

Features

Prebiotics and mixed fiber sources to support GI conditions

Clinically proven to improve stool quality and result in quicker resolution of actute diarrhea4

Highly digestible5

ST-O-ne GUARD formulated to manage urolithiasis1

Recommended for

Acute or Chronic Gastroenteritis

Gastritis/Ulcers

Small & Large Bowel Diarrhea

Motility/Emptying Disorders

Feline Hairballs

Exocrine Pancreatic Insufficiency

Chronic Enteropathies

Antibiotic-Responsive Diarrhea

Colitis

Constipation

Intestinal Dysbiosis

Diets_Feline_KM.png

K+M

Kidney + Mobility Support

Formulated to address two common ailments in cats, this veterinary-exclusive formula contains controlled protein and mineral levels to support healthy kidney function, plus Glucosamine and Chondroitin to help with overall mobility.

Features

Controlled protein levels, controlled phosphorus, controlled sodium

Rich in EPA and DHA

With added L-carnitine, Vitamin E, and Carotenoids

Highly digestible protein sources (chicken, egg)

Suitable for all IRIS stages

Highly palatable

Nutrition to benefit animals with cardiac disease6

High digestibility

Glucosamine and chondroitin in cats along with extra EPA/DHA, antioxidants

Clinically shown to maintain lean muscle mass in senior cats over 6 months13

ST-O-ne GUARD formulated for calcium oxalate prevention

Indications

Kidney disease

Calcium oxalate urolithiasis

Cardiac disease

Joint disease

Not recommended for

Struvite urolithiasis

Growth, pregnancy or lactation

Diets_Feline_WU.png

W+U

Weight Management + Urinary Care

For cats who need help with weight management and urinary care, this veterinary-exclusive formula is made with the ideal levels of fat and calories to help cats with weight loss, plus controlled mineral levels to support urinary health.

Features

Clinically shown to dissolve struvite uroliths in as little as 14 days in cats15

Clinically proven nutrition to generate a urine a pH of 6.0-6.48

Controlled magnesium, sodium, and other mineral levels to limit urolith formation9

High in mixed fiber sources such as flaxseed, chicory root, and cellulose to promote satiety and prevent weight loss

Moderately high protein levels to help improve glycemic control10

Clinically proven nutrition to lower serum insulin and leptin levels with weight loss11

L-carnitine to decrease body fat and maintain lean muscle12

Clinically proven nutrition to reduce body fat by 34.7% and body weight by 12.5% in just two months11

Betaine to support fat oxidation12 and help protect against hepatic lipidosis16

ST-O-ne GUARD formulated to dissolve and prevent struvite urolithiasis and prevent calcium oxalate urolithiasis7

Indications

Weight Management

Weight management for obese or overweight cats

Helps to maintain lean muscle mass

Dissolution of pure struvite uroliths

Urinary Care

Cats prone to lower urinary tract disease

Helps to limit the formation of struvite uroliths

Helps to limit the formation of calcium oxalate urolithiasis

Not recommended for

Growth, pregnant, or lactating life stages

Use of concurrent urinary acidifier

“I have become a huge advocate of BLUE Natural Veterinary Diet™. The efficacy and palatability of the ingredients and formulation of the diet have aided in my treatment protocols. More importantly, pet owners have come to trust in the BLUE brand.”

Dr. Daniel Choi, DVM, MBA from Graceful Animal Hospital, Rancho Cucamonga, CA

“I am happy with the palatability, digestibility testing, and technology, of BLUE Natural Veterinary Diet™. I am especially pleased to hear our clients say their pets were picky and now LOVE to eat. I feel confident using BLUE NVD in my patients, so much so I use them in my own pets.”

Ashley Detwiler, DVM, DACVD from Pittsburgh Veterinary Dermatology

“BLUE Natural Veterinary Diet™ offers unique combinations of features and benefits that work well for patient management. Blue Buffalo is a company that I have come to trust and rely on over the years and what I most appreciate is their support and transparency. They are a welcome addition to the landscape of veterinary therapeutic diets.”

Donna M. Raditic DVM, ACVIM (Nutrition), Board Certified Veterinary Nutritionist® from Nutrition and Integrative Medicine Consultants

“I highly recommend the HF diet: pets love it, and it has proven to be an excellent tool for managing food allergies in both dogs and cats. I've been impressed with the very positive results in skin health and overall happiness of my food-allergic patients.”

Carine Laporte, VMD, DACVD from Dermatology for Animals, Salt Lake City, UT

  1. Blue Buffalo Company, Ltd., data on file, 2018.
  2. Blue Buffalo Co., Ltd., data on file, 2015.
  3. Lewis, T. et. al. Evaluation of a new hydrolyzed salmon-based diet in dogs with suspected cutaneous adverse food reaction: a multi-center randomized triple-blinded clinical trial. Abstract presentation at NAVDF April 2019. Austin, TX.
  4. Frantz NZ et al. Novel food with mixed soluble fiber promotes quicker resolution of acute diarrhoea in shelter kittens. J Anim Physiol Anim Nutr. 2020; 104:406.; Frantz NZ et al. Novel food with mixed soluble fiber promotes stool improvements and resolution of acute diarrhoea in shelter puppies. J Anim Physiol Anim Nutr. 2020; 104:406.
  5. Blue Buffalo Company Ltd., data on file, 2016-2018.
  6. Freeman, L. Nutritional Management of Cardiac Disease. WSAVA World Congress Proceedings, 2013. North Grafton, MA; Freeman, L. Optimal Nutrition in Cats with Heart Disease. ACVIM 2014. North Grafton, MA.; Sanderson, SL. Taurine and carnitine in canine cardiomyopathy. Vet. Clin. North Am. Small Anim. Pract. 2006. Nov:3 6(6):1325-43, vii-viii.; Oxidative Stress in Dogs with Heart Failure: The Role of Dietary Fatty Acids and Antioxidants, Emmanuelle Sagols and Nathalie Priymenko, Vet Med. Int. 2011.
  7. Blue Buffalo Co., Ltd., data on file, 2021; Stevenson A. & Rutgers C. Nutritional Management of Canine Urolithiasis. In: Encyclopedia of Canine Clinical Nutrition. Eds: Pibot P, Biourge V., Elliott D. 2006. Aniwa SAS Pgs. 284-315; 8 Houston DM et al. A diet with a struvite relative supersaturation less than 1 is effective in dissolving struvite stones in vivo. Br J Nutr 2011; 106: S90-S92.
  8. Blue Buffalo Co., Ltd., data on file, 2021.
  1. Osborne CA et al. Canine struvite urolithiasis: Causes, detection, management and prevention. In: Hand M et al. Small animal clinical nutrition. 5th ed. Topeka, Ka: Morris Animal Institute, 2012: 891-914.
  2. Zicker S et al. Endocrine Disorders. In: Hand M et al. Small Animal Clinical Nutrition. 5th Ed. Topeka, KS: Mark Morris Institute, 2010. pp 568-569.. Virtual, June 2-3, 2021.
  3. Panasevich M et al. Serum biomarkers predict improved body composition in overweight dogs fed a therapeutic diet. In Proceedings AAVN Clinical Nutrition & Research Symposium. Virtual, June 2-3, 2021.; Panasevich M et al. Improved body composition is linked to serum biomarkers in overweight cats fed a therapeutic diet. In Proceedings AAVN Clinical Nutrition & Research Symposium. Virtual, June 2-3, 2021.
  4. Toll PW et al. Obesity. In: Hand M et al. Small animal clinical nutrition. 5th ed. Topeka, Kan: Morris Animal Institute, 2012: 501-542.
  5. Frantz NZ et al. Novel food containing antioxidants and fish oil improves mobility scores in arthritic dogs. In Proceedings AAVN Clinical Nutrition & Research Symposium. Virtual, June 10-11, 2020.
  6. Toll PW et al. Obesity. In: Hand M et al. Small animal clinical nutrition. 5th ed. Topeka, Kan: Morris Animal Institute, 2012: 501-542) and help protect against hepatic lipidosis (Verbrugghe A et al. Peculiarities of one-carbon metabolism in the strict carnivorous cat and the role in feline hepatic lipidosis. Nutrients 2013; 5: 2811-2835.
  7. Tefft KM et al. Effect of a struvite dissolution diet in cats with naturally occurring struvite urolithiasis. J Fel Med Sur. 2020. https://doi.org/10.1177/1098612X20942382.
  8. Verbrugghe A et al. Peculiarities of one-carbon metabolism in the strict carnivorous cat and the role in feline hepatic lipidosis. Nutrients 2013; 5: 2811-2835.